What browsers should we be validating against?

Thought I'd ask out front. Should Opera be included? Safari? (I'd guess so)...What do you all test against? I would guess the bulk of the world would work with IE, Firefox and Chrome...
I am working on a Mac so Safari is kinda a standard now but work is always in a PC environment so I know the others need to be there. The question comes from Chaotic's Firefox vs IE downloads. I' m wondering what holes can be run into in the two browsers. Also - what is it actually being written in? I'm currently using TextMate on the Mac - any recommendations?
I am working on a Mac so Safari is kinda a standard now but work is always in a PC environment so I know the others need to be there. The question comes from Chaotic's Firefox vs IE downloads. I' m wondering what holes can be run into in the two browsers. Also - what is it actually being written in? I'm currently using TextMate on the Mac - any recommendations?